“There Is No Such Thing As An Antidepressant.”
“We really don’t have good enough evidence that antidepressants are effective and we have increasing evidence that they can be can be harmful. So we need to go into reverse and stop this increasing trend of prescribing them.” Joanna Moncrieff, a psychiatrist and researcher at University College London. Scientific American.
… numerous studies of norepinephrine and serotonin metabolites in plasma, urine, and cerebrospinal fluid as well as postmortem studies of the brains of patients with depression, have yet to identify the purported deficiency reliably.
“And where there is a scientific vacuum, drug companies are happy to insert a marketing message and call it science. As a result, psychiatry has become a proving ground for outrageous manipulations of science in the service of profit.”
“Drug-placebo differences in antidepressant efficacy increase as a function of baseline severity, but are relatively small even for severely depressed patients. The relationship between initial severity and antidepressant efficacy is attributable to decreased responsiveness to placebo among very severely depressed patients, rather than to increased responsiveness to medication.”
“While only half of these trials had formally significant effectiveness, published reports almost ubiquitously claimed significant results. ‘Negative’ trials were either left unpublished or were distorted to present ‘positive’ results.” This article ends with the statement: “Nevertheless, even if one feels a bit depressed by this state of affairs, there is no reason to take antidepressants, they probably won’t work.”